Much of the phenotypic variation that is observed within and between species is the result of differences in gene regulation: specifically when, where and how much the genes are expressed. Given the ...

Missing genes and sequencing read registration in single-cell RNA-seq experiments. Credit: Nature Methods (2023). DOI: 10.1038/s41592-023-02003-w In 2018, researchers in the Caltech laboratory of Yuki ...

Scientists at the Broad Institute and Mass General Brigham have built a generative AI model that creates short DNA segments ...

Researchers at the Jackson Laboratory (JAX), the Broad Institute of MIT and Harvard, and Yale University, have used artificial intelligence (AI) to design thousands of new DNA switches that can ...

Researchers at the Mount Sinai Center for Transformative Disease Modeling used multi-omics genetic analysis tools to identify 4,749 key gene clusters, termed “prognostic modules,” which they say ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

A recent study marks the first reported instance of generative AI designing synthetic molecules that can successfully control gene expression in healthy mammalian cells. As a proof-of-concept, the ...

Summary: A team of investigators from Dana-Farber Cancer Institute, The Broad Institute of MIT and Harvard, Google, and Columbia University have created an artificial intelligence model that can ...

Gene Expression Data Show Direct Impact on the Core Biology of IPF ...

Epigenetics is the study of various heritable alterations that control gene expression without changing the DNA sequence. 1 The name epigenetics comes from the Greek prefix “epi”, which means on top ...

What do your genes have to do with growing old? Quite a lot. But is it due to the actual DNA, or the way those genes are expressed? KPBS sci-tech reporter Thomas Fudge has more on new research that ...