Nature

MHC Class II Molecules and Dendritic Cell Function

MHC class II molecules are central to the adaptive immune response, serving as the means by which antigen-presenting cells, notably dendritic cells, display processed peptides to CD4+ T cells. This ...
WNDU

Medical Moment: Child with MHC Class II deficiency receives life-saving treatment

(WNDU) - Genetic disorders are caused by an abnormality in a person’s DNA. 10 out of 1,000 babies born will be diagnosed with one. In fact, 17% of couples are at a high risk of transmitting a genetic ...
ascopubs.org

First-line chemoimmunotherapy in metastatic breast carcinoma: Effect of a combination of paclitaxel and LAG-3-ig (IMP321), a novel MHC class II agonist, on T-cell responses and ...

A phase I study of bevacizumab in combination with sunitinib, sorafenib, and erlotinib plus cetuximab, and trastuzumab plus lapatinib. Background: IMP321 is a recombinant soluble LAG-3Ig fusion ...
Hosted on MSN

Review highlights emerging role of tumor MHC-II in shaping cancer immunotherapy outcomes

Cancer immunotherapy has transformed cancer treatment, yet many patients experience limited or short-lived responses due to immune evasion, tumor heterogeneity, and immune-related adverse events.
ascopubs.org

Single nucleotide polymorphisms (SNPs) in MHC class I and II genes to predict outcome in patients (pts) with metastatic colorectal cancer (mCRC): Data from FIRE-3, MAVERICC ...

Analysis of primary and acquired resistance to cetuximab from multiomic data in the New EPOC trial. This is an ASCO Meeting Abstract from the 2023 ASCO Annual Meeting I. This abstract does not include ...