Nature

HIV-1 Reverse Transcriptase Inhibitors

HIV-1 reverse transcriptase inhibitors have long been central to antiretroviral therapy, effectively impeding the enzyme responsible for converting viral RNA into DNA – a pivotal step in HIV ...
BioWorld

Reverse transcriptase inhibitors can prevent cancer drug resistance

Retrotransposons could have a main role in the development of drug resistance in response to cancer treatment, according to a new study out of the Roswell Park Comprehensive Cancer Center. The ...
Business Wire

ROME Therapeutics Demonstrates Efficacy of its Novel LINE-1 Reverse Transcriptase Inhibitor in Translational Models of Autoimmune Disease

BOSTON--(BUSINESS WIRE)--ROME Therapeutics, a biotechnology company harnessing the power of the dark genome to develop breakthrough medicines for cancer and autoimmune diseases, today announced it ...
Medscape

Clinical Significance of HIV Reverse-transcriptase Inhibitor-resistance Mutations

† Drugs combined with NRTIs or NRTIs/NNRTIs are not listed. NNRTIs: Non-nucleoside reverse-transcriptase inhibitors; NRTIs: Nucleos(t)ide analog reverse-transcriptase inhibitors. Drug-resistance amino ...
Medscape

Resistance Associated With Reverse Transcriptase Inhibitors

At the 12th International HIV Drug Resistance Workshop, held June 10-14, 2003, in Los Cabos, Mexico, investigators from around the world provided the latest results from studies of resistance topics ...
News Medical

HIV drug stops disease progression in 25% of patients with fourth-line metastatic colorectal cancer

New clinical research shows that lamivudine, a reverse transcriptase inhibitor widely used in HIV therapy, stopped disease progression in 25% of patients with fourth-line metastatic colorectal cancer.
Monthly Prescribing Reference

Reverse Transcriptase Inhibitor Fast Tracked for Progressive Supranuclear Palsy

After 48 weeks of treatment, TPN-101 reduced the levels of neurofilament light chain and interleukin 6, both key biomarkers of neurodegeneration and neuroinflammation in PSP. The Food and Drug ...
Science Daily

HIV drug stabilizes disease progression in metastatic colorectal cancer

Many cancers exhibit high levels of the reverse transcriptase enzyme. Single-agent lamivudine, a reverse transcriptase inhibitor, stopped disease progression in over 25% of patients with fourth-line ...
JSTOR Daily

Intermittent Episodes of Detectable HIV Viremia in Patients Receiving Nonnucleoside Reverse-Transcriptase Inhibitor-Based or Protease Inhibitor-Based Highly Active ...

This is a preview. Log in through your library . Abstract Background. Intermittent episodes of detectable human immunodeficiency virus (HIV) viremia (hereafter referred to as "blips") are generally ...
Pharmabiz

Merck announces positive results from phase 3 study of non-nucleoside reverse transcriptase inhibitor, doravirine to treat HIV-1 infection

Merck, known as MSD outside the United States and Canada, has announced the presentation of results from the DRIVE-AHEAD study, the second of two pivotal phase 3 clinical trials evaluating the ...
BioWorld

Rome Therapeutics raises new funds to advance LINE-1 reverse transcriptase inhibitor into clinic

BioWorld - Tuesday, December 24, 2024 Breaking News: Holiday special – 25% off BioWorld subscriptions See today's BioWorld Science Home » Rome Therapeutics raises new funds to advance LINE-1 reverse ...