Spatial proteomics enables scientists to investigate protein organization at the subcellular, cellular, and tissue levels, including in pathological contexts. Using technologies that help researchers ...

Researchers have gained new insights into the mechanism behind the spatial organization of DNA within the cells of early embryos. When an embryo is first formed after fertilization, each cell has the ...

In a recent study published in Nature, researchers investigate the spatial organization of cancer cells and the tumor microenvironment by analyzing over one hundred tumor sections across six types of ...

Lucy Shapiro received this year’s Lasker Special Achievement Award for her discovery of how bacteria use genetic circuits to encode three-dimensional cellular life. “I was quite shocked, truly,” said ...

Left: Imaging of lamin A/C structures in a physically expanded nucleus from an individual with progeria. Right: Same, but with 3D genomic reads overlaid in their original spatial locations, colored by ...

Challenges and Prospects. Challenges and prospects faced by spatial transcriptomics itself and its application to the musculoskeletal system. AI Artificial intelligence, FFPE Formalin fixed and ...

An international research team has provided a detailed insight into how the spatial organization of genetic material is established in the cell nucleus of early embryos within the first hours after ...

Conventional transcriptomic techniques have revealed much about gene expression at the population and single-cell level—but they overlook one crucial factor: spatial context. In musculoskeletal ...

Spatial organization of proteins (dots) within a human cell: Each protein is placed according to its relationships with others; cellular compartments are denoted by color. During infection, some ...