A Mendelian randomization study reveals PCSK9 inhibitors may reduce low back pain (LBP) risk, while HMGCR and NPC1L1 inhibitors show no significant association, providing genetic evidence for ...

Researchers argue that, in some situations where machine-learning models are used to allocate scarce resources or opportunities, randomizing decisions in a structured way may lead to fairer outcomes.

The influence of dietary compounds on aging is a rapidly growing field of research. Amino acids, the building blocks of proteins, could play a surprising role in lifespan. A team of researchers from ...

A new research paper was published in Volume 18 of Aging-US on February 6, 2026, titled "Causal effects of inflammation on long-term mortality: a Mendelian randomization study." ...

A research team analyzed linguistic approaches to help cancer patients better comprehend the concept of randomization, being assigned by chance to treatment or control groups, in clinical trials.

The genetic and clinical heterogeneity of breast cancer makes the identification of effective therapies challenging. We designed I-SPY 2, a phase 2, multicenter, adaptively randomized trial to screen ...

The heterogeneity of breast cancer makes identifying effective therapies challenging. The I-SPY 2 trial, a multicenter, adaptive phase 2 trial of neoadjuvant therapy for high-risk clinical stage II or ...